Data & Publications

Novel Mitochondrial Protective Agent for Parkinson’s Disease Targeting the PINK1/LRRK2 Axis
Sherine S. L. Chan, Emmaline Bendell, Jesse McClure, C. James Chou
Neurotherapeutics. 2024. 21(4):e00416

Discovery of the First Vitamin K Analog as a Potential Treatment of Pharmacoresistant Seizures
Li X*, Himes RA, Prosser LC, Christie CF, Watt E, Edwards SF, Metcalf C, West P, Wilcox K, Chan SSL*, Chou CJ*. J Med Chem. 2020. PMID: 32390424

Novel Vitamin K Analogues Suppress Seizures in Zebrafish and Mouse Models of Epilepsy
Jennifer J. Rahn, Jennifer E. Bestman, Benjamin J. Josey, Elizabeth S. Inks, Krista D. Stackley, Carolyn E. Rogers, C. James Chou, and Sherine S. L. Chan
Neuroscience. 2014 Feb 14; 259: 142–154.

​Structure-Activity Relationship Study of Vitamin K Derivatives Yields Highly Potent Neuroprotective Agents
Benjamin J. Josey, Elizabeth S. Inks, Xuejun Wen, and C. James Chou
J Med Chem. 2013 Feb 14; 56(3): 1007–1022.

Vitamin K: A Structural Basis for the Design of Novel Neuroprotective Agents?
C James Chou, Elizabeth S Inks, and Benjamin J Josey
Future Med Chem. 2013. 5(8):857-60

Inherited Mitochondrial Genomic Instability and Chemical Exposures
Sherine S.L.Chan
Toxicology. 2017 391:75-83

HDAC1 Localizes to the Mitochondria of Cardiac Myocytes and Contributes to Early Cardiac Reperfusion Injury
Daniel J. Herr, Mauhamad Baarine, Sverre E. Aune, Xiaoyang Li, Lauren E. Ball, John J. Lemasters, Craig C. Beeson, James C. Chou, and Donald R. Menick
J Mol Cell Cardiol. 2018 Jan; 114: 309–319.